Progressive Vaccinia

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Pneumocystis Carinii Penumonia and Progressive Vaccinia in Siblings.

The occurrence of Pneumocystis carinii pneumonia and progressive vaccinia in siblings, associated with hypogammaglobulinaemia, has already been recorded (McKay and Richardson, 1959). A similar combination in siblings described here seems worthy of record, because the gamma globulin value in the sib with progressive vaccinia was probably within normal limits, and in both patients there seems to ...

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Necropsy findings in a case of progressive vaccinia.

A case of progressive vaccinia complicating chronic lymphocytic leukaemia is reported. At necropsy a vaccinial pneumonia, focal pancreatitis, and evidence of disseminated intravascular coagulation were found. Epithelial proliferation was noted in sweat glands, bronchi, and pancreatic ducts associated with lesions in these sites. The significance of these findings is discussed.

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Pneumocystis Carinii Pneumonia and Progressive Vaccinia in Siblings

The occurrence of Pneumocystis carinii pneumonia and progressive vaccinia in siblings, associated with hypogammaglobulinaemia, has already been recorded (McKay and Richardson, 1959). A similar combination in siblings described here seems worthy of record, because the gamma globulin value in the sib with progressive vaccinia was probably within normal limits, and in both patients there seems to ...

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A case of vaccinia necrosum (or progressive vaccinia), with severe hypogammaglobulinaemia, treated with n-methyl isatin beta-thiosemicarbazone (33T57).

A fatal case of vaccinia necrosum treated with antivaccinial gamma globulin and N-methyl isatin beta-thiosemicarbazone (33T57) is described. Histological abnormalities found at necropsy included intranuclear as well as cytoplasmic inclusion bodies, absence of lymphoid germinal centres, grey hepatization, and bronchiolar epithelial hyperplasia. Virus titres were highest in the original skin lesi...

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Efficacy of cidofovir in a murine model of disseminated progressive vaccinia.

An animal model that mimics progressive disseminated vaccinia was elaborated. To this end nude (athymic) mice were inoculated intracutaneously with vaccinia virus in the lumbosacral area. Viral replication (DNA) in the skin was detected as early as day 2 postinfection (p.i.). Mice developed typical vaccinia lesions at the site of inoculation by day 4 to 6 p.i. By about 2 weeks p.i., the infecti...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2003

ISSN: 1058-4838,1537-6591

DOI: 10.1086/374244